Caspase 2 anticorps (AA 417-439)

N° du produit ABIN3030294

Détail du produit anti-Caspase 2 anticorps

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Épitope: AA 417-439

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 2 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids 417-439 (REGYAPGTEFHRCKEMSEYCSTL) were used as the immunogen for this Caspase-2 antibody (100% homologous in human, mouse and rat). This sequence is from the small subunit.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Caspase-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Caspase-2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Caspase 2

Antigène: Caspase 2 (CASP2) (Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2))

Autre désignation: Caspase-2 (CASP2 Produits)

Synonymes: anticorps xCaspase-2, anticorps Caspase-2, anticorps ICH-1, anticorps Nedd2, anticorps CASP-2, anticorps ICH1, anticorps NEDD-2, anticorps NEDD2, anticorps PPP1R57, anticorps ICH-1L/1S, anticorps ICH1L1S, anticorps caspase 2, anticorps caspase 2 L homeolog, anticorps caspase-2, anticorps CASP2, anticorps casp2.L, anticorps CpipJ_CPIJ008254, anticorps Casp2

Sujet: Caspase-2/CASP2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. Activation of Caspase-2 occurs in a complex that contains the death domain-containing protein PIDD, whose expression is induced by p53, and the adaptor protein RAIDD. Increased PIDD expression resulted in spontaneous activation of Caspase-2 and sensitization to apoptosis by genotoxic stimuli. CASP2 acts both as a positive and negative cell death effector, depending upon cell lineage and stage of development.

UniProt: P42575

Pathways: Apoptose, Caspase Cascade in Apoptosis, Neurotrophin Signaling Pathway