NLRP3 anticorps (AA 21-194)

N° du produit ABIN3032019

Cet anticorps anti-NLRP3 est un anticorps Lapin Polyclonal détectant NLRP3 dans WB. Adapté pour Humain.

Aperçu rapide pour NLRP3 anticorps (AA 21-194) (ABIN3032019)

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NLRP3 anticorps

Épitope: AA 21-194

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (21-194) was used as the immunogen for this NLRP3 / NALP3 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the NALP3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the NALP3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur NLRP3

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Autre désignation: NALP3 (NLRP3)

Sujet: NLR Family, Pyrin domain containing 3, also known as CIAS1, CRYOPYRIN, NALP3 or PYPAF1, is a protein that in humans is encoded by the NLRP3 gene. It is mapped to 1q44. The encoded protein may play a role in the regulation of inflammation and apoptosis. Consistent with an essential role for NALP3 inflammasomes in antifungal immunity, it has been showed that deficient mice are hypersusceptible to C. albicans infection. Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells. The inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance.

ID gène: 114548

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome