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RRM2B anticorps (C-Term)

RRM2B Reactivité: Humain, Rat, Souris WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3032475
  • Antigène Voir toutes RRM2B Anticorps
    RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
    Épitope
    • 15
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 39
    • 35
    • 20
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 51
    • 3
    Lapin
    Clonalité
    • 51
    • 3
    Polyclonal
    Conjugué
    • 22
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RRM2B est non-conjugé
    Application
    • 47
    • 24
    • 13
    • 13
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogène
    An amino acid sequence from the C-terminus of human p53 reductase small subunit 2 (EGKTNFFEKRVSEYQ) was used as the immunogen for this p53R2 antibody (100% homologous in human, mouse and rat).
    Isotype
    IgG
    Top Product
    Discover our top product RRM2B Anticorps primaire
  • Indications d'application
    The stated application concentrations are suggested starting amounts. Titration of the p53R2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Stock
    -20 °C
    Stockage commentaire
    After reconstitution, the p53R2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Antigène
    RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
    Autre désignation
    p53R2 (RRM2B Produits)
    Synonymes
    anticorps p53r2, anticorps RRM2B, anticorps MTDPS8A, anticorps MTDPS8B, anticorps P53R2, anticorps p53R2, anticorps ribonucleotide reductase M2 B (TP53 inducible) S homeolog, anticorps ribonucleotide reductase regulatory TP53 inducible subunit M2B, anticorps ribonucleotide reductase M2 B (TP53 inducible), anticorps rrm2b.S, anticorps RRM2B, anticorps rrm2b, anticorps Rrm2b
    Sujet
    Ribonucleotide Reductase, M2 B, also known as P53R2, is an enzyme that in humans is encoded by the RRM2B gene. Tanaka et al.(2000) mapped the gene to chromosome 8q23.1 by fluorescence in situ hybridization. Tanaka et al.(2000) found that expression of p53R2, but not R2, was induced by ultraviolet and gamma-irradiation and adriamycin treatment in a wildtype p53-dependent manner. Induction of p53R2 in p53-deficient cells caused G2/M arrest and protected cells from death in response to adriamycin. Inhibition of endogenous p53R2 expression in cells that had an intact p53-dependent DNA damage checkpoint reduced ribonucleotide reductase activity, DNA repair, and cell survival after exposure to various genotoxins.
    UniProt
    Q7LG56
    Pathways
    Signalisation p53, Negative Regulation of intrinsic apoptotic Signaling
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