FRZB anticorps (AA 176-325)

N° du produit ABIN3042406

Détail du produit anti-FRZB anticorps

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Épitope: AA 176-325

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRZB est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 3(FRZB) detection. Tested with WB, ELISA in Human.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 3(FRZB) detection. Tested with WB, ELISA in Human.
Gene Name: frizzled-related protein
Protein Name: Secreted frizzled-related protein 3

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for FRZB is approximately 0.1 ng/lane under reducing conditions.
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur FRZB

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Autre désignation: FRZB (FRZB Produits)

Synonymes: anticorps Frp, anticorps Sfrp3, anticorps frezzled, anticorps fritz, anticorps frzb-1, anticorps FRE, anticorps FRITZ, anticorps FRP-3, anticorps FRZB-1, anticorps FRZB-PEN, anticorps FRZB1, anticorps FZRB, anticorps OS1, anticorps SFRP3, anticorps SRFP3, anticorps hFIZ, anticorps Frzb-1, anticorps frizzled-related protein, anticorps Frzb, anticorps FRZB

Sujet: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

Synonyms: FIZ antibody|FRE antibody|Frezzled antibody|Fritz antibody|Frizzled-related protein 1 antibody|FRP antibody|FrzB 1 antibody|FRZB antibody|FRZB1 antibody|OTTMUSP00000014350 antibody|RP23-33L19.1 antibody|Secreted frizzled related protein 3 [Precursor] antibody|Secreted frizzled related sequence protein 3 antibody|sFRP 3 antibody|SFRP antibody

ID gène: 2487

UniProt: Q92765

Pathways: Signalisation WNT, Positive Regulation of fat Cell Differentiation