RAB8A anticorps (C-Term)

N° du produit ABIN3042554

L’anticorps Lapin Polyclonal anti-RAB8A a été validé pour WB et IHC. Il convient pour détecter RAB8A dans des échantillons de Humain.

Aperçu rapide pour RAB8A anticorps (C-Term) (ABIN3042554)

Antigène: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAB8A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-RAB8A anticorps

Épitope: AA 170-183, C-Term

Fonction: Anti-Ras-related protein Rab-8A RAB8A Antibody Picoband®

Séquence: KAKMDKKLEG NSPQ

Réactivité croisée (Details): No cross-reactivity with other proteins

Attributs du produit: Anti-Ras-related protein Rab-8A RAB8A Antibody (ABIN3042554). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human RAB8A, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
1. "Entrez Gene: RAB8A RAB8A, member RAS oncogene family" 2. Tsang, W. Y., Bossard, C., Khanna, H., Peranen, J., Swaroop, A., Malhotra, V., Dynlacht, B. D. CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficiency in human ciliary disease. Dev. Cell 15: 187-197, 2008. 3. Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (October 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene 6 (8): 1347-51.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur RAB8A

Antigène: RAB8A (RAB8A, Member RAS Oncogene Family (RAB8A))

Autre désignation: RAB8A

Sujet:

Synonyms: Ras-related protein Rab-8A,Oncogene c-mel,RAB8A,MEL, RAB8,

Tissue Specificity: Expressed in brain, placenta and lung. .

Background: Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene. It is mapped to 19p13.12. The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. RAB8A regulates cilia assembly by targeting and promoting fusion of vesicles near the ciliary membrane. This gene requires CEP290 for centrosome localization and that CEP290 regulates entry of RAB8A into the cilium during assembly of this organelle. RAB8A has been shown to interact with Optineurin and MAP4K2.

Sequence Similarities: Belongs to the beta-catenin family.

Poids moléculaire: 24 kDa

UniProt: P61006

Pathways: M Phase, Regulation of long-term Neuronal Synaptic Plasticity, SARS-CoV-2 Protein Interactome