CCL2 anticorps (AA 24-99)

N° du produit ABIN3042598

Détail du produit anti-CCL2 anticorps

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Épitope: AA 24-99

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCL2 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Rabbit IgG polyclonal antibody for C-C motif chemokine 2(CCL2) detection. Tested with WB, ELISA in Human.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for C-C motif chemokine 2(CCL2) detection. Tested with WB, ELISA in Human.
Gene Name: chemokine (C-C motif) ligand 2
Protein Name: C-C motif chemokine 2

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human MCP-1 recombinant protein (Position: Q24-T99). Human MCP-1 shares 60.9% and 59.4% amino acid (aa) sequence identity with mouse and rat MCP-1, respectively.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-CCL2 (ABIN3042598)

Qian, Feng, Sun, Xiong, Ding, Han, Chen, Chen, Du, Wang: "Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model." dans: BioMed research international, Vol. 2018, pp. 8973986, (2019) (PubMed).

Xie, Li, Pi, Wu, Zeng, Zuo, Zha: "[Down-regulation of p38 MAPK and collagen by 1, 25-(OH)2-VD3 in rat models of diabetic nephropathy]." dans: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, Vol. 32, Issue 7, pp. 931-5, (2017) (PubMed).

Li, Lu, Sun, Zuo, Wang, Yan: "Inhibition of endoplasmic reticulum stress signaling pathway: A new mechanism of statins to suppress the development of abdominal aortic aneurysm." dans: PLoS ONE, Vol. 12, Issue 4, pp. e0174821, (2017) (PubMed).

Wu, Chang, Ren, Hu, Li, Liu: "Bindarit reduces the incidence of acute aortic dissection complicated lung injury via modulating NF-κB pathway." dans: Experimental and therapeutic medicine, Vol. 14, Issue 3, pp. 2613-2618, (2017) (PubMed).

Sun, Zhang, Zhao, Zhen, Huang, Wang, He, Liu, Xu, Yang, Qu, Ma, Zhang, Zhang, Hu: "Attenuation of atherosclerotic lesions in diabetic apolipoprotein E-deficient mice using gene silencing of macrophage migration inhibitory factor." dans: Journal of cellular and molecular medicine, Vol. 19, Issue 4, pp. 836-49, (2016) (PubMed).

Huang, Li, Niu, Xiao, Pu, Zheng, Qian: "Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation." dans: Biomedical engineering online, Vol. 14, pp. 55, (2016) (PubMed).

Sun, Fan, Wang, Lu, Zhang, Wu, Shan, Zheng: "Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome." dans: The Journal of nutritional biochemistry, Vol. 26, Issue 10, pp. 1029-40, (2015) (PubMed).

Peng, Mao, Fu, Feng, Xu: "Comparison of biomarkers in rat renal ischemia-reperfusion injury." dans: International journal of clinical and experimental medicine, Vol. 8, Issue 5, pp. 7577-84, (2015) (PubMed).

Liu, Li, Qiu, He: "Expression and cellular distribution of TLR4, MyD88, and NF-?B in diabetic renal tubulointerstitial fibrosis, in vitro and in vivo." dans: Diabetes research and clinical practice, Vol. 105, Issue 2, pp. 206-16, (2014) (PubMed).

Tian, Lv, Yang, Zhang, Yu, Zhu, Xiao, Zhu: "Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats." dans: International journal of clinical and experimental pathology, Vol. 7, Issue 6, pp. 3028-37, (2014) (PubMed).

Zhang, Wang, Ma, Liu, Zhang, Zhu: "Effect of herba centellae on the expression of HGF and MCP-1." dans: Experimental and therapeutic medicine, Vol. 6, Issue 2, pp. 427-434, (2013) (PubMed).

Sun, Bu, Liu, Yin, Zhou, Li, Xiao: "Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction." dans: PLoS ONE, Vol. 8, Issue 5, pp. e65042, (2013) (PubMed).

Liu, Wang, Yang, Wang, Yang, Liu, Ye: "Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor ?1 expression in human renal epithelial cells." dans: Molecular medicine reports, Vol. 5, Issue 5, pp. 1241-4, (2012) (PubMed).

Lu, Zhu, Liang, Cui, Liu, Wu, Liang, Liu, Jiang, Liao, Xie, Zhou, Wu, Yuan, Liao: "Apelin-APJ induces ICAM-1, VCAM-1 and MCP-1 expression via NF-?B/JNK signal pathway in human umbilical vein endothelial cells." dans: Amino acids, Vol. 43, Issue 5, pp. 2125-36, (2012) (PubMed).

Zhang, Li, Li, Zhao, Su, Zhang, Zhang, Miao: "Lipopolysaccharide activated phosphatidylcholine-specific phospholipase C and induced IL-8 and MCP-1 production in vascular endothelial cells." dans: Journal of cellular physiology, Vol. 226, Issue 6, pp. 1694-701, (2011) (PubMed).

Xu, Feng, Wang, Zhu, Lin, Lou, Xiang, He, Zheng, Tang, Zuo: "Phytoestrogen calycosin-7-O-?-D-glucopyranoside ameliorates advanced glycation end products-induced HUVEC damage." dans: Journal of cellular biochemistry, Vol. 112, Issue 10, pp. 2953-65, (2011) (PubMed).

Ji, Gao, Cai, Lu, Hu, Wang, Cheng, Gu, Wan, Zhang, Cao: "Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model." dans: Journal of ethnopharmacology, Vol. 134, Issue 3, pp. 624-9, (2011) (PubMed).

Li, Wang, Yang, Zhang, Han, Wang: "Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats." dans: Acta pharmacologica Sinica, Vol. 32, Issue 2, pp. 217-22, (2011) (PubMed).

He, Liang, Hou, Guo, Xie, Zhang: "Ethanol extraction of Picrorhiza scrophulariiflora prevents renal injury in experimental diabetes via anti-inflammation action." dans: The Journal of endocrinology, Vol. 200, Issue 3, pp. 347-55, (2009) (PubMed).

Li, Hou, Zhang, Chen, Liu, Feng, Liu, Shan, Wang, Zhou, Tian, Xie: "Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model." dans: Journal of the American Society of Nephrology : JASN, Vol. 18, Issue 2, pp. 528-38, (2007) (PubMed).

Détails sur CCL2

Antigène: CCL2 (Chemokine (C-C Motif) Ligand 2 (CCL2))

Autre désignation: CCL2 (CCL2 Produits)

Synonymes: anticorps GDCF-2, anticorps HC11, anticorps HSMCR30, anticorps MCAF, anticorps MCP-1, anticorps MCP1, anticorps SCYA2, anticorps SMC-CF, anticorps AI323594, anticorps JE, anticorps Scya2, anticorps Sigje, anticorps MCP-1A, anticorps MCP1A, anticorps C-C motif chemokine ligand 2, anticorps chemokine (C-C motif) ligand 2, anticorps C-C motif chemokine 2, anticorps CCL2, anticorps Ccl2, anticorps LOC101120093

Sujet: Monocyte chemoattractant protein-1 (MCP-1), a member of the chemokine (chemotactic cytokine) family, is a potent monocyte agonist that is upregulated by oxidized lipids. MCP-1 is also known as CCL2, SCYA2, MCAF. MCAF is a member of family of factors involved in immune and inflammatory responses. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of a putative signal peptide sequence of 23 amino acid residues and a mature MCAF sequence of 76 amino acid residues. MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder. Human MCP-1 is a 8.7KDa non-glycoprotein, consisting of 99 amino acids in precursor form and 76 amino acids in mature form.

Synonyms: C-C motif chemokine 2 antibody|CCL 2 antibody|CCL2 antibody|CCL2_HUMAN antibody|Chemokine (C C motif) ligand 2 antibody|Chemokine C C motif ligand 2 antibody|Chemokine CC Motif Ligand 2 antibody|GDCF 2 antibody|GDCF 2 HC11 antibody|GDCF-2 antibody|GDCF2 antibody|HC11 antibody|HSMCR30 antibody|HSMCR30 antibody|JE antibody|MCAF antibody|MCP 1 antibody|MCP-1 antibody|MCP1 antibody|MGC9434 antibody| Monocyte chemoattractant protein 1 antibody|Monocyte chemotactic and activating factor antibody|Monocyte chemotactic and activating factor antibody|Monocyte chemotactic protein 1 antibody|Monocyte secretory protein JE antibody|SCYA2 antibody|Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je) antibody|Small inducible cytokine A2 antibody|Small inducible cytokine subfamily A (Cys Cys), member 2 antibody|Small inducible cytokine subfamily A Cys Cys member 2 antibody|Small-inducible cytokine A2 antibody|SMC CF antibody|SMC-CF antibody|SMCCF antibody

ID gène: 6347

UniProt: P13500

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, ER-Nucleus Signaling, Unfolded Protein Response, Phosphorylation & l'infection par le SRAS-CoV-2