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CDK4 anticorps (C-Term)

CDK4 Reactivité: Humain, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3042691
  • Antigène Voir toutes CDK4 Anticorps
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Épitope
    • 22
    • 16
    • 16
    • 9
    • 9
    • 9
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 283-303, C-Term
    Reactivité
    • 119
    • 76
    • 54
    • 19
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Rat
    Hôte
    • 107
    • 34
    • 2
    • 1
    Lapin
    Clonalité
    • 106
    • 37
    Polyclonal
    Conjugué
    • 83
    • 11
    • 11
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CDK4 est non-conjugé
    Application
    • 121
    • 55
    • 37
    • 31
    • 21
    • 19
    • 16
    • 15
    • 14
    • 13
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for Cyclin-dependent kinase 4(CDK4) detection. Tested with WB in Human,Mouse,Rat.
    Séquence
    RISAFRALQH SYLHKEESDA E
    Réactivité croisée (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Cyclin-dependent kinase 4(CDK4) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: cyclin-dependent kinase 4
    Protein Name: Cyclin-dependent kinase 4
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence at the C-terminus of mouse Cdk4(283-303aa RISAFRALQHSYLHKEESDAE), different from the related rat sequence by one amino acid, and from the related human sequence by four amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CDK4 Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • Ren, Huang, Xu, Yang, Yang, Hu: "Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells." dans: Anti-cancer drugs, Vol. 26, Issue 6, pp. 599-611, (2015) (PubMed).

    Zhou, Lu, Liu, Guo, Liu, Zhou, Yang, Mi, Xu: "Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo." dans: Current cancer drug targets, Vol. 14, Issue 9, pp. 860-71, (2015) (PubMed).

    Zhang, Zhao, Huang, Meng, Bian, Li: "Melittin restores PTEN expression by down-regulating HDAC2 in human hepatocelluar carcinoma HepG2 cells." dans: PLoS ONE, Vol. 9, Issue 5, pp. e95520, (2014) (PubMed).

    Wang, Huang, Han, Xue, Li, Liu, Shan, Wang, Li, Li: "The effects of artemisinin on the proliferation and apoptosis of vascular smooth muscle cells of rats." dans: Cell biochemistry and function, Vol. 32, Issue 2, pp. 201-8, (2014) (PubMed).

    Li, Xu, Chu, Gao, Wang, Nie, Yang, Lv: "Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice." dans: Immunology letters, Vol. 156, Issue 1-2, pp. 68-81, (2013) (PubMed).

    Cai, Xu, Zhang: "Bone marrow stromal cells induce cell cycle arrest in reactive astrocytes in vitro." dans: Neuroscience letters, Vol. 522, Issue 1, pp. 62-6, (2012) (PubMed).

    Li, Xu, Li, Zou, Saimaiti, Simayi, Wang, Zhang, Yuan, Zhang: "Stat6 activity-related Th2 cytokine profile and tumor growth advantage of human colorectal cancer cells in vitro and in vivo." dans: Cellular signalling, Vol. 24, Issue 3, pp. 718-25, (2012) (PubMed).

    Zhang, Ge, Sun, Cao, Wu, Guo, Wang: "Effect of bone morphogenetic protein-2 on proliferation and apoptosis of gastric cancer cells." dans: International journal of medical sciences, Vol. 9, Issue 2, pp. 184-92, (2012) (PubMed).

    Liu, Dai, Lu, Wei, Ha, Rong, Mu, You, Li, Guo: "LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression." dans: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 89, Issue 3, pp. 287-98, (2011) (PubMed).

    Han, Liu: "EGR-1 decoy ODNs inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia of balloon-injured arteries in rat." dans: Life sciences, Vol. 86, Issue 7-8, pp. 234-43, (2010) (PubMed).

  • Antigène
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Autre désignation
    CDK4 (CDK4 Produits)
    Synonymes
    anticorps zgc:153726, anticorps CMM3, anticorps PSK-J3, anticorps Crk3, anticorps 8-6, anticorps CDK4, anticorps CDK4/6, anticorps CG5072, anticorps Cdk4/6, anticorps DmCdk4, anticorps Dmel\\CG5072, anticorps Pk53C, anticorps Pk?7, anticorps cdk, anticorps cdk4, anticorps cdk4/6, anticorps dCdk4, anticorps l(2)05428, anticorps l(2)0671, anticorps l(2)k06503, anticorps l(2)s4639, anticorps l(2)sh0671, anticorps xcdk4, anticorps cyclin-dependent kinase 4, anticorps cyclin dependent kinase 4, anticorps Cyclin-dependent kinase 4, anticorps cyclin-dependent kinase 4 L homeolog, anticorps cdk4, anticorps CDK4, anticorps Cdk4, anticorps cdk4.L
    Sujet
    Cyclin-dependent kinase-4(CDK4) is a protein-serine kinase involved in the cell cycle. Human cell division is regulated primarily at the G1-to-S or the G2-to-M boundaries within the cell cycle. The complexes formed by CDK4 and the D-type cyclins are involved in the control of cell proliferation during the G1 phase. CDK4 is inhibited by p16, also known as cyclin-dependent kinase inhibitor-2. CDK4 is mapped to 12q14. CDK4 expression and activity are required for cytokine responsiveness in T cells.

    Synonyms: Cdk 4 antibody|cdk4 antibody|CDK4 protein antibody|CDK4_HUMAN antibody|Cell division kinase 4 antibody|Cell division protein kinase 4 antibody|CMM 3 antibody|CMM3 antibody|Crk3 antibody|Cyclin dependent kinase 4 antibody|Cyclin-dependent kinase 4 antibody|Melanoma cutaneous malignant 3 antibody|MGC14458 antibody|p34 cdk4 antibody|PSK J3 antibody|PSK-J3 antibody
    UniProt
    P30285
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size
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