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Growth Hormone Receptor anticorps (Middle Region)

GHR Reactivité: Souris, Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3043066
  • Antigène Voir toutes Growth Hormone Receptor (GHR) Anticorps
    Growth Hormone Receptor (GHR)
    Épitope
    • 16
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 231-247, Middle Region
    Reactivité
    • 54
    • 31
    • 31
    • 17
    • 16
    • 2
    • 1
    Souris, Rat
    Hôte
    • 52
    • 4
    Lapin
    Clonalité
    • 43
    • 13
    Polyclonal
    Conjugué
    • 25
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Growth Hormone Receptor est non-conjugé
    Application
    • 37
    • 19
    • 15
    • 14
    • 14
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Fonction
    Rabbit IgG polyclonal antibody for Growth hormone receptor(GHR) detection. Tested with WB in Mouse,Rat.
    Séquence
    DKEHEVRVRS RQRSFEK
    Réactivité croisée (Details)
    No cross reactivity with other proteins.
    Attributs du produit
    Rabbit IgG polyclonal antibody for Growth hormone receptor(GHR) detection. Tested with WB in Mouse,Rat.
    Gene Name: growth hormone receptor
    Protein Name: Growth hormone receptor(GH receptor)
    Purification
    Immunogen affinity purified.
    Immunogène
    A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor(231-247aa DKEHEVRVRSRQRSFEK), identical to the related rat sequence.
    Isotype
    IgG
    Top Product
    Discover our top product GHR Anticorps primaire
  • Indications d'application
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Mouse, Rat
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Commentaires

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Agent conservateur
    Thimerosal (Merthiolate), Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Date de péremption
    12 months
  • Antigène
    Growth Hormone Receptor (GHR)
    Autre désignation
    GHR (GHR Produits)
    Synonymes
    anticorps GHBP, anticorps AA986417, anticorps GHR/BP, anticorps GHR, anticorps ghr, anticorps ghr.a, anticorps zgc:162141, anticorps growth hormone receptor, anticorps growth hormone receptor L homeolog, anticorps growth hormone receptor a, anticorps GHR, anticorps Ghr, anticorps ghr.L, anticorps ghr, anticorps ghra
    Sujet
    The GHR locus to human chromosome 5p13.1-p12 and to mouse chromosome 15. Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb. GHR consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are 2 isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3(d3GHR). Furthermore, the two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing. In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the GHR gene have been demonstrated as the cause of Laron syndrome , also known as the growth hormone insensitivity syndrome(GHIS).

    Synonyms: GH receptor antibody|GH-binding protein antibody|GHBP antibody|GHBP, included antibody|GHR antibody|GHR_HUMAN antibody|Growth hormone binding protein antibody|Growth hormone receptor antibody|Growth hormone receptor precursor antibody|Growth hormone-binding protein antibody|Growth hormone-binding protein, included antibody|Increased responsiveness to growth hormone, included antibody|Serum binding protein antibody|Serum-binding protein antibody|Somatotropin receptor antibody
    UniProt
    P16882
    Pathways
    Signalisation NF-kappaB, Signalistation JAK/STAT, Response to Growth Hormone Stimulus
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