Cytochrome C anticorps (full length)

N° du produit ABIN306559

Cet anticorps Mouton Polyclonal détecte spécifiquement Cytochrome C dans WB, IHC et IP. Il présente une réactivité avec des échantillons de Humain, Rat, Chien et Lapin.

Aperçu rapide pour Cytochrome C anticorps (full length) (ABIN306559)

Antigène: Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))

Reactivité: Humain, Rat, Chien, Lapin

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp Cytochrome C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-Cytochrome C anticorps

Épitope: full length

Fonction: Sheep anti Human Cytochrome c

Réactivité croisée: Humain

Attributs du produit: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

Purification: Ammonium Sulfate Precipitation

Immunogène: Full length recombinant Cytochrome C

Isotype: IgG

Information d'application

Indications d'application: Applications: Western Blot 1:5,000, shows a MW of 14.4 kDa. May be used in immunofluorescence applications with human and rat cells, Immunoprecipitation - Empirical.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur Cytochrome C

Antigène: Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))

Autre désignation: Cytochrome c

Sujet: Sheep anti cytochrome c, cyto c, cytochrome-c

UniProt: P99999, P62898, P00008, P00011

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity