Cyclin E1 anticorps
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- Antigène Voir toutes Cyclin E1 (CCNE1) Anticorps
- Cyclin E1 (CCNE1)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Cyclin E1 est non-conjugé
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Application
- Western Blotting (WB)
- Clone
- F2-2-38
- Isotype
- IgG2a
- Top Product
- Discover our top product CCNE1 Anticorps primaire
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- Indications d'application
- Antibody detects human cyclin E protein by Western blot. Detects a 50 kDa band.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/ml
- Stock
- -20 °C
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- Antigène
- Cyclin E1 (CCNE1)
- Autre désignation
- cyclin E (CCNE1 Produits)
- Synonymes
- anticorps CCNE1, anticorps ccne, anticorps cyclinE, anticorps CCNE, anticorps AW538188, anticorps CycE1, anticorps CYCLE, anticorps Ccne, anticorps cyce2, anticorps cycE3, anticorps cyce, anticorps fa18e07, anticorps wu:fa18e07, anticorps cyclin E1, anticorps cyclin E1 L homeolog, anticorps cyclin E1 S homeolog, anticorps CCNE1, anticorps ccne1, anticorps Ccne1, anticorps ccne1.L, anticorps ccne1.S
- Sujet
- Human cyclin E was originally identified by complementation of a triple cln deletion in Saccharomyces cerevisiae. Following the identification of human cyclin E protein, researchers found that breast cancers and some other solid tumors exhibited both quantitative and qualitative alterations in cyclin E protein production. In particular, the alterations in cyclin E expression in breast cancer correlated with increasing stage and grade of the tumor. These results suggested that cyclin E might be useful as a prognostic marker. More recently, Geng et al generated a mouse strain in which the coding sequences for cyclin D1 was deleted and replaced with those of human cyclin E. Replacement of cyclin D1 with cyclin E rescued all phenotypic manifestations seen in the cyclin D1 deficient mice and restored normal development to cyclin D1-dependent tissues. Based on the results of these studies, it appears that cyclin E is the major downstream target of cyclin D1.In addition to functioning downstream of cyclin D1, recent studies with Xenopus egg extracts demonstrated that cyclin E localizes to the centrosome. In these studies CDK2-cyclin E activity was shown to be required for centrosome duplication during S phase. Taken together, these data suggest a mechanism that coordinates centrosome reproduction with cycles of DNA synthesis and mitosis. Synonyms: G1/S-specific cyclin E1, CCNE1.
- UniProt
- P24864
- Pathways
- Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
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