Caspase 7 anticorps
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- Antigène Voir toutes Caspase 7 (CASP7) Anticorps
- Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Caspase 7 est non-conjugé
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Application
- Western Blotting (WB)
- Réactivité croisée
- Humain
- Attributs du produit
- Cysteine-requiring Aspartate Protease-7, Apoptotic protease Mch-3, ICE-like apoptotic protease 3,Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha fodrin, NuMA and others. Caspase-7 is a 303 amino acid protein with high similarity to caspase-3. Caspase-7 occurs in three varient forms. Granzyme B activates pro-caspase-7 to a form which can cleave poly(ADP-ribose) polymerase (PARP) to its signature fragment of ~85 kDa. Also, in vivo caspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7 has been shown to exist as dimers or high order oligomers. Caspase-7 may be an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic T-lymophocyte-induced cell killing in vivo.
- Purification
- Ammonium Sulfate Precipitation
- Immunogène
- Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human caspase-7 protein and mouse myeloma cells.
- Clone
- MCH3-5
- Isotype
- IgG
- Top Product
- Discover our top product CASP7 Anticorps primaire
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- Indications d'application
- Detects proenzyme form of human Caspase-7 by Western blot. Optimal concentration should be evaluated by serial dilutions.
- Restrictions
- For Research Use only
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- Buffer
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- Antigène
- Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))
- Autre désignation
- Caspase-7 (CASP7 Produits)
- Synonymes
- anticorps xCaspase-7, anticorps caspase-7, anticorps caspase7, anticorps cmh-1, anticorps ice-lap3, anticorps mch3, anticorps CASP7, anticorps AI314680, anticorps CMH-1, anticorps ICE-IAP3, anticorps Mch3, anticorps mCASP-7, anticorps CASP-7, anticorps ICE-LAP3, anticorps LICE2, anticorps MCH3, anticorps Caspase-7, anticorps MCH3/SCA-2, anticorps SCA-2, anticorps caspase 7, anticorps caspase-7, anticorps caspase 7 S homeolog, anticorps CASP7, anticorps xcaspase-7, anticorps casp7, anticorps casp7.S, anticorps Casp7
- UniProt
- P55210
- Pathways
- Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
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