HNF4A anticorps

N° du produit ABIN317780

Détail du produit anti-HNF4A anticorps

Antigène: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNF4A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of HNF4α protein.(region surrounding Lys298)

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-HNF4A (ABIN317780)

Hu, Ma, Huang, Mao, Yang, Zhao, Li, Qiu, Yang, Zheng, Wang: "Dihydrocapsaicin Attenuates Plaque Formation through a PPAR?/LXR? Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet." dans: PLoS ONE, Vol. 8, Issue 6, pp. e66876, (2013) (PubMed).

He, Xiao, Zhang, Ma, Li, Yang: "Detection and functional annotation of misregulated microRNAs in the brain of the Ts65Dn mouse model of Down syndrome." dans: Chinese medical journal, Vol. 126, Issue 1, pp. 108-13, (2013) (PubMed).

Détails sur HNF4A

Antigène: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Autre désignation: HNF4 alpha / TCF14 (HNF4A Produits)

Synonymes: anticorps HNF4A, anticorps HNF4alpha, anticorps CG9310, anticorps DmHNF4, anticorps Dmel\\CG9310, anticorps HNF-4, anticorps HNF-4(D), anticorps HNF4, anticorps Hnf-4, anticorps Hnf-4h, anticorps NR2A4, anticorps dHNF-4, anticorps dHNF4, anticorps Hnf4, anticorps Hnf4alpha, anticorps MODY1, anticorps Nr2a1, anticorps Tcf14, anticorps HNF4a7, anticorps HNF4a8, anticorps HNF4a9, anticorps MODY, anticorps NR2A1, anticorps NR2A21, anticorps TCF, anticorps TCF14, anticorps HNF-4alpha, anticorps fb58h09, anticorps id:ibd1279, anticorps wu:fb58h09, anticorps hnf4, anticorps nr2a1, anticorps hepatocyte nuclear factor 4 alpha, anticorps Hepatocyte nuclear factor 4, anticorps hepatic nuclear factor 4, alpha, anticorps hepatocyte nuclear factor 4, alpha, anticorps hepatocyte nuclear factor 4 alpha S homeolog, anticorps HNF4A, anticorps hnf4a, anticorps Hnf4, anticorps Hnf4a, anticorps hnf4a.S

Sujet: HNF-1 (α and β), HNF-3 (α, β and γ), HNF-4 (α and γ), and HNF-6 compose, in part, a homoeprotein family designated the Hepatocyte Nuclear Factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3α, HNF-3β and HNF-3γ regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3α and HNF-3β have also been shown to be involved in gastrulation events such as body axis formation. HNF-4α and HNF-4γ have been shown to be important for early embryo development. HNF-4α is expressed in liver, kidney, pancreas, small intestine, testis and colon, and HNF-4γ is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3β, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and α-1 antitrypsin.Synonyms: HNF4, HNF4A, Hepatocyte nuclear factor 4-alpha, NR2A1, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, Transcription factor HNF-4

Poids moléculaire: 52 kDa

ID gène: 3172

NCBI Accession: NP_000448

UniProt: P41235

Pathways: AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process