FZD2 anticorps

N° du produit ABIN317860

Cet anticorps Lapin Polyclonal détecte spécifiquement FZD2 dans WB et IF. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour FZD2 anticorps (ABIN317860)

Antigène: FZD2 (Frizzled Family Receptor 2 (FZD2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-FZD2 anticorps

Specificité: This antibody detects endogenous levels of Frizzled-2 protein.(region surrounding Glu240)

Purification: Affinity Chromatography using epitope-specific immunogen

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur FZD2

Antigène: FZD2 (Frizzled Family Receptor 2 (FZD2))

Autre désignation: FZD2 / Frizzled-2

Sujet: The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The frizzled proteins contain seven transmembrane domains, a cysteine-rich domain in the extracellular region and a carboxy-terminal Ser/Thr-XXX-Val motif. The proteins in this family function as receptors for Wnt and are generally coupled to G proteins. Frizzleds are members of the G protein-coupled receptor superfamily. Frizzled-2 is expressed in the fetal kidney and lung and in the adult ovary and colon. Frizzled-2 mediates the Wnt/cGMP/Ca2+ pathway. It binds Wnt proteins and signals by activating the release of stored calcium. Frizzled-2 expression is regulated by Angiotensin II. Activated frizzled-2 suppresses the activity of protein kinase G, and activates NFAT-dependent transcription, the phosphatidylinositol pathway and calcium sensitive enzymes.Synonyms: Fz-2, FzE2, hFz2

Poids moléculaire: approx. 55 kDa

ID gène: 2535

NCBI Accession: NP_001457

UniProt: Q14332

Pathways: Signalisation WNT