PAK4 anticorps
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- Antigène Voir toutes PAK4 Anticorps
- PAK4 (P21-Activated Kinase 4 (PAK4))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PAK4 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- PAK4/5/6 antibody detects endogenous levels of PAK4/5/6 protein.(region surrounding Val469)
- Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse and Rat.
- Purification
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product PAK4 Anticorps primaire
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- Indications d'application
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ELISA: 1/5000approx. 1/10000. Western Blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % Sodium Azide as preservative, approx. pH 7.2.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- PAK4 (P21-Activated Kinase 4 (PAK4))
- Autre désignation
- PAK4 (PAK4 Produits)
- Synonymes
- anticorps 5730488L07Rik, anticorps AW555722, anticorps mKIAA1142, anticorps im:5916170, anticorps wu:fd12b01, anticorps zgc:92014, anticorps p21 (RAC1) activated kinase 4, anticorps p21 protein (Cdc42/Rac)-activated kinase 4, anticorps PAK4, anticorps Pak4, anticorps pak4
- Sujet
- Three recently identified isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiaekinase STE20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.Synonyms: KIAA1142, KIAA1264, PAK 4, PAK-4, PAK-5, PAK-5, PAK-6, PAK-7, PAK5, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK 6, Serine/threonine-protein kinase PAK 7, p21-activated kinase 4, p21-activated kinase 5, p21-activated kinase 6, p21-activated kinase 7
- Poids moléculaire
- approx. 80 kDa
- ID gène
- 10298
- NCBI Accession
- NP_001014831
- UniProt
- O96013
- Pathways
- Signalisation RTK
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