CD44 anticorps

N° du produit ABIN317946

Cet anticorps anti-CD44 est un anticorps Lapin Polyclonal détectant CD44 dans WB. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour CD44 anticorps (ABIN317946)

Antigène: CD44

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD44 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CD44 anticorps

Specificité: This antibody detects endogenous levels of CD44 protein.(region surrounding Glu702)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD44

Antigène: CD44

Autre désignation: CD44

Sujet: Cell adhesion molecules (CAMs) are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and play an important role in embryogenesis and development. HCAM (also designated CD44) is a member of the CAM family and participates in the progression of IgA nephropathy by binding hyaluronic acid and osteopontin. The colocalization of osteopontin in the bladder epithelium with αVβ3 integrin and HCAM suggests a role for HCAM in maintaining the integrity of the transitional epithelium by providing the sealing and adhesiveness needed for the impermeable state of the bladder. HCAM is closely related to the secretory phase of the normal menstrual cycle and its expression is decreased in hyperplasia and in cancer cases. Decreased HCAM expression may be functionally involved in the multiple mechanisms of the development and progression of endometrial lesions.Synonyms: CDw44, ECMR-III, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, LHR, MDU2, MDU3, MIC4, PGP-1, Phagocytic glycoprotein 1

Poids moléculaire: approx. 90 kDa

ID gène: 960

NCBI Accession: NP_000601

UniProt: P16070

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling