NGFR anticorps

N° du produit ABIN318704

L’anticorps Lapin Polyclonal anti-NGFR a été validé pour WB et IF. Il convient pour détecter NGFR dans des échantillons de Humain et Souris.

Aperçu rapide pour NGFR anticorps (ABIN318704)

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NGFR est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-NGFR anticorps

Specificité: This antibody recognises CD271, a transmembrane protein of 70-75 kDa, otherwise known as Nerve Growth Factor Receptor (NGFR).

Purification: Purified

Immunogène: Recombinant human CD271

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1g/mL, detects a band of approximately 75-80 kDa in A-20 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide (NaN3)

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NGFR

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Autre désignation: CD271 / NGFR

Sujet: CD 271 is a pro-apoptotic member of the tumour necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4. CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signalling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination. Mutations and changes in CD271 expression have been implicated in various pathological diseases including AlzheimerSynonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16

ID gène: 4804

NCBI Accession: NP_002498

UniProt: P08138

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding