Tyrosine Hydroxylase anticorps (pSer40)

N° du produit ABIN319111

Détail du produit anti-Tyrosine Hydroxylase anticorps

Antigène: Tyrosine Hydroxylase (TH)

Épitope: pSer40

Reactivité: Humain, Rat, Souris, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Tyrosine Hydroxylase est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody reacts to is specific for Tyrosine Hydroxylase, when phosphorylated at serine 40.

Purification: Affinity chromatography

Immunogène: Synthetic phosphopeptide corresponding to an amino acid sequence within Tyrosine Hydroxylase which includes phosphorylated Ser 40.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on frozen sections: 1: 1000. Western Blot: 1: 1000,detects a band of approximately 60 kDa in PC-12 cell lysates,following stimulation by Okadaic acid. Immunofluorescence: 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES, pH 7.5 containing 0.09 % Sodium Azide, 0.01 % Bovine Serum Albumin and 50 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Tyrosine Hydroxylase

Antigène: Tyrosine Hydroxylase (TH)

Autre désignation: Tyrosine 3-Monooxygenase (TH) (TH Produits)

Synonymes: anticorps DYT14, anticorps DYT5b, anticorps TYH, anticorps The, anticorps CG10118, anticorps DH65B, anticorps DTH, anticorps Dmel\\CG10118, anticorps Pale, anticorps Ple, anticorps TH, anticorps Th, anticorps VII, anticorps dTH1, anticorps dTH65B, anticorps pale/ple, anticorps th, anticorps dyt14, anticorps dyt5b, anticorps tyh, anticorps tyrosine hydroxylase, anticorps pale, anticorps tyrosine 3-monooxygenase, anticorps tyrosine hydroxylase S homeolog, anticorps TH, anticorps Th, anticorps ple, anticorps th, anticorps th.S, anticorps LOC100008895

Sujet: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthetic pathway of the catecholamines dopamine (DA), norepinephrine, and epinephrine. The enzyme exists as a tetramer, with each subunit composed of an N-terminal regulatory domain and a C-terminal catalytic domain. Phosphorylation of TH has been shown to occur at several serine residues. Phosphorylation at serine 40 results in an increase in hydroxylase activity, and phosphorylation at serine 19 is reported to promote phosphorylation of the serine 40 residue. Tyrosine hydroxylase is regularly used as a marker for dopaminergic neurons, which is particularly relevant for research into ParkinsonSynonyms: TYH, Tyrosine 3-hydroxylase

ID gène: 7054

NCBI Accession: NP_000351

UniProt: P07101

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour