Aurora A anticorps (pThr288)

N° du produit ABIN319281

Cet anticorps anti-Aurora A Polyclonal Lapin (ABIN319281) détecte spécifiquement Aurora A dans IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Aurora A anticorps (pThr288) (ABIN319281)

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aurora A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Aurora A anticorps

Épitope: pThr288

Specificité: Aurora A (phospho-Thr288) Antibody AP08036PU detects endogenous levels of Aurora A only when phosphorylated at Threonine 288.

Purification: Immunoaffinity Chromatography: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène: The antiserum was produced against synthesized phosphopeptide derived from human Aurora A around the phosphorylation site of Threonine 288 (R-T-TP-L-M).

Information d'application

Indications d'application: Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at-20 °C.

Détails sur Aurora A

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Autre désignation: Aurora Kinase A

Sujet: Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Synonyms: AIK1, ARK1, AURA, AURKA, AURORA2, Aurora/IPL1-related kinase 1, BTAK, Breast tumor-amplified kinase, STK15, STK6, Serine/threonine kinase 15, Serine/threonine-protein kinase 6

ID gène: 6790

NCBI Accession: NP_003591

UniProt: O14965

Pathways: Cycle Cellulaire, Asymmetric Protein Localization