Retinoblastoma 1 anticorps (pThr821)

N° du produit ABIN3201013

Détail du produit anti-Retinoblastoma 1 anticorps

Antigène: Retinoblastoma 1 (RB1)

Épitope: pThr821

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoblastoma 1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: Specific to human Rb phosphorylated at Thr821.

Réactivité croisée (Details): Not tested for other species. Can detect endogenous levels of Rb phosphorylated at Thr821 in most cell lines.

Purification: Purified

Stérilité: Sterile filtered

Immunogène: A synthetic peptide containing pThr821 of human Rb

Clone: 24A7

Isotype: IgG1 kappa

Information d'application

Indications d'application: 1. Western blotting: ~1 g/mL
2. ELISA
Other applications were not tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Store at -20 C (For long term storage: -70 C).

Références pour anticorps anti-Retinoblastoma 1 (ABIN3201013)

Sherr: "Cancer cell cycles." dans: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, (1997) (PubMed).

Welch, Wang: "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle." dans: Cell, Vol. 75, Issue 4, pp. 779-90, (1993) (PubMed).

Nevins: "E2F: a link between the Rb tumor suppressor protein and viral oncoproteins." dans: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 424-9, (1992) (PubMed).

Hu, Dyson, Harlow: "The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations." dans: The EMBO journal, Vol. 9, Issue 4, pp. 1147-55, (1990) (PubMed).

Détails sur Retinoblastoma 1

Antigène: Retinoblastoma 1 (RB1)

Autre désignation: RB (RB1 Produits)

Synonymes: anticorps OSRC, anticorps RB, anticorps p105-Rb, anticorps pRb, anticorps pp110, anticorps Rb, anticorps Rb-1, anticorps P105-RB, anticorps PP110, anticorps RB11, anticorps zgc:154147, anticorps RB transcriptional corepressor 1, anticorps RB transcriptional corepressor like 1, anticorps retinoblastoma 1, anticorps RB1, anticorps RBL1, anticorps Rb1, anticorps rb1

Sujet: Retinoblastoma protein (Rb), the tumor suppressor product of the retinoblastoma susceptibility gene, is a 110 kDa protein that functions as a negative regulator of the cell cycle by arresting cells in the G1 phase and halting inappropriate cell proliferation. At the transcriptional level, Rb protein exerts its growth suppressive function by binding to transcription factors including E2F1, PU1, ATF2, UBF, Elf-1 and c-Abl. Loss of Rb function leads to uncontrolled cell growth and tumor development and is found in all retinoblastomas and in a variety of other human malignancies. The ability of Rb protein to inhinbit transcription and cell cycle progression is inactivated by hosphorylation, which is catalyzed by the cyclin-dependent protein kinases.

UniProt: P06400

Pathways: Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy