BST1 anticorps

N° du produit ABIN356330

L’anticorps Souris Monoclonal anti-BST1 a été validé pour IF, IHC (fro) et IHC (p). Il convient pour détecter BST1 dans des échantillons de Humain.

Aperçu rapide pour BST1 anticorps (ABIN356330)

Antigène: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BST1 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TN218

Détail du produit anti-BST1 anticorps

Attributs du produit: Synonyms: Blood Group Tn Antigen

Purification: PBS, pH 7.4 containing 0.05% Sodium Azide as preservative.

Immunogène: Asialo ovine submaxillary mucin (AOSM). Remarks: Molecular weight of antigen: Several HM weight glycoproteins. Epitope: alpha GalNacOSer/Thr.

Isotype: IgM

Information d'application

Indications d'application: Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears)For IHC dilute concentared antibody at 1/50-1/100, use streptavidinapprox. biotin system orpolymer system, incubate 30 minutes at room temperature. Immunofluorescence. Recommended Positive Control: Human gastrointestinal tumor.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Date de péremption: 12 months

Détails sur BST1

Antigène: BST1 (Bone Marrow Stromal Cell Antigen 1 (BST1))

Autre désignation: CD175

Sujet: Aberrant glycosylation is a hallmark of cancer cells. The blood group precursors T (Thomsen-Friedenreich) and Tn epitopes are shielded in healthy and benign-diseased tissues but uncovered in approx. 90 % of carcinomas. T and Tn glycoproteins are specific, autoimmunogenic pancarcinoma antigens. These antigens may also be found in neoplastic blood cells Fundamental chemical and physical aspects of these glycoproteins of primary carcinomas are discussed first. Tn and T epitopes are cell and tissue adhesion molecules, essential in invasion by and metastasis of carcinoma which includes adherent and proliferative phases. Immunohistochemical studies of the extent of Tn antigen expression in primary breast carcinoma demonstrate it highly significant correlation with clinicopathological tumor stages, and hence its value as a reliable prognosticator.Synonyms: Blood Group Tn Antigen