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SETD7 anticorps (Middle Region)

SETD7 Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN356694
  • Antigène Voir toutes SETD7 Anticorps
    SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
    Épitope
    • 16
    • 7
    • 7
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 66
    • 18
    • 10
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Humain, Souris
    Hôte
    • 55
    • 10
    • 1
    Lapin
    Clonalité
    • 52
    • 13
    • 1
    Polyclonal
    Conjugué
    • 33
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SETD7 est non-conjugé
    Application
    • 57
    • 29
    • 25
    • 17
    • 13
    • 13
    • 12
    • 10
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody is specific to SET7 (SET9) (Center).
    Purification
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogène
    This SET7/9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human SET9.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SETD7 Anticorps primaire
  • Indications d'application
    ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
    Autre désignation
    SETD7 / SET9 (SETD7 Produits)
    Synonymes
    anticorps KMT7, anticorps SET7, anticorps SET7/9, anticorps SET9, anticorps set7, anticorps zgc:101860, anticorps zgc:92330, anticorps 1600028F23Rik, anticorps H3K4MT, anticorps Set7, anticorps Set7/9, anticorps mKIAA1717, anticorps SET domain containing lysine methyltransferase 7, anticorps SET domain containing (lysine methyltransferase) 7, anticorps SETD7, anticorps setd7, anticorps Setd7
    Sujet
    Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.Synonyms: H3-K4-HMTase SETD7, Histone H3-K4 methyltransferase SETD7, Histone-lysine N-methyltransferase SETD7, KIAA1717, KMT7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7, SET7/9
    ID gène
    80854, 9606
    UniProt
    Q8WTS6
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