ERN2 anticorps (N-Term)

N° du produit ABIN359268

Détail du produit anti-ERN2 anticorps

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to ERN2 / IRE2.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ERN2.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur ERN2

Antigène: ERN2 (Endoplasmic Reticulum To Nucleus Signaling 2 (ERN2))

Abstract: ERN2 Produits

Synonymes: anticorps Ire1beta, anticorps ire1b, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps IRE1-BETA, anticorps IRE1b, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN2, anticorps ern2, anticorps Ern2

Sujet: ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.Synonyms: Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, Ire1-beta, Serine/threonine-protein kinase/endoribonuclease IRE2

ID gène: 10595, 9606

UniProt: Q76MJ5