FGFR2 anticorps (N-Term)

N° du produit ABIN359854

Détail du produit anti-FGFR2 anticorps

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to FGFR2.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human FGFR2.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur FGFR2

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Autre désignation: CD332 / FGFR-2 (FGFR2 Produits)

Synonymes: anticorps FGFR2, anticorps FGFR2IIIb, anticorps bek, anticorps bfr-1, anticorps cd332, anticorps cek3, anticorps cfd1, anticorps ect1, anticorps fgfr-2, anticorps jws, anticorps k-sam, anticorps kgfr, anticorps tk14, anticorps tk25, anticorps xfgfr2, anticorps DKFZp469H1521, anticorps BBDS, anticorps BEK, anticorps BFR-1, anticorps CD332, anticorps CEK3, anticorps CFD1, anticorps ECT1, anticorps JWS, anticorps K-SAM, anticorps KGFR, anticorps TK14, anticorps TK25, anticorps AU043015, anticorps AW556123, anticorps Bek, anticorps Fgfr-2, anticorps Fgfr-7, anticorps Fgfr7, anticorps KGFRTr, anticorps svs, anticorps FGF-R, anticorps fgfr72IIIb, anticorps FGFR, anticorps fc56c05, anticorps wu:fc56c05, anticorps fibroblast growth factor receptor 2, anticorps fibroblast growth factor receptor 2 L homeolog, anticorps FGFR2, anticorps LOC100084641, anticorps fgfr2, anticorps Fgfr2, anticorps fgfr2.L

Sujet: FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.Synonyms: BEK, FGFR2, Fibroblast growth factor receptor 2, KGFR, KSAM, Keratinocyte growth factor receptor 2

ID gène: 2263, 9606

UniProt: P21802

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding