IL-6 Receptor anticorps (Extracellular Domain)

N° du produit ABIN360909

Cet anticorps anti-IL-6 Receptor est un anticorps Rat Monoclonal détectant IL-6 Receptor dans WB et IHC (fro). Adapté pour Souris.

Aperçu rapide pour IL-6 Receptor anticorps (Extracellular Domain) (ABIN360909)

Antigène: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-6 Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 14F33

Détail du produit anti-IL-6 Receptor anticorps

Épitope: Extracellular Domain

Specificité: This antibody detects Mouse IL-6R. Other species not tested.

Purification: Protein A/G affinity chromatography

Immunogène: Recombinant protein of IL-6R extracellular domain.

Isotype: IgG2

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 0.2 mL sterile PBS and the final concentration is 0.5 mg/mL.

Buffer: PBS, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur IL-6 Receptor

Antigène: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Autre désignation: CD126 / IL6R

Sujet: IL6 exerts its activity through binding to a high affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa IL6 binding receptor protein (IL6R) and a 130 kDa signal transducing protein consisting of a 19 amino acid residue signal peptide (gp130). Human IL6R is a 468 amino acid residue type I membrane protein consisting of a 19 amino acid residue signal peptide, a 339 residue extracellular region, a 28 residue transmembrane region and an 82 residue cytoplasmic region. The ectodomain of IL6R is made up of an immunoglobulin like domain and a cytokine receptor superfamily domain. A naturally occurring soluble form of the IL6R, which binds IL6 and which mediates IL6 signaling through interaction with gp130, is identified in the urine of healthy adult humans. It has also been detected in human and mouse serum as well as in the conditioned medium of various cells including human peripheral blood mononuclear cells, and several T cell or granulocyte/macrophage cell lines. Increased expression of the c-fos and c-myc protooncogenes have been linked to IL6 receptor activation.Synonyms: IL-6R 1, IL-6R-alpha, IL6 Receptor alpha, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80

ID gène: 16194

NCBI Accession: NP_034689

UniProt: P22272

Pathways: Signalistation JAK/STAT, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints