Klotho anticorps

N° du produit ABIN360924

Cet anticorps anti-Klotho est un anticorps Rat Monoclonal détectant Klotho dans WB et IHC (fro). Adapté pour Souris.

Aperçu rapide pour Klotho anticorps (ABIN360924)

Antigène: Klotho (KL)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Klotho est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 4F54

Détail du produit anti-Klotho anticorps

Specificité: This antibody detects Mouse Klotho. Other species not tested.

Purification: Protein A/G Affinity Chromatography

Stérilité: 0.2 μm filtered

Immunogène: Purified Mouse Recombinant protein of Klotho

Isotype: IgG2

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry on frozen sections: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: 0.2 μm filtered solution in PBS, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Klotho

Antigène: Klotho (KL)

Autre désignation: Klotho

Sujet: Animal models of human aging which display the characteristic diseases associated with aging provide insight into the cause of such diseases. Recently a transgenic mouse model, called Klotho, with several premature aging phenotypes has been described. They display premature aging phenotypes such as Osteoporosis, age related skin changes, ectopic calcifications, atrophy of genital organs and thymus, emphysema and short life span. Klotho (Kl) protein associated with the Klotho mutation is a 1014 amino acid long peptide. It has a putative signal sequence at its N-terminus and a single transmembrane domain near its C-terminus, which is postulated to anchor it to the membrane. kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway. KL has been reported to be localized on the cell surface when expressed on Cho cells. Human kl cDNA is expected to encode a protein of 1012 amino acids.Synonyms: EC 3.2.1.31, KL, Klotho

ID gène: 16591

NCBI Accession: NP_038851

UniProt: O35082

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding