RAGE anticorps (Extracellular Domain)

N° du produit ABIN360934

Cet anticorps Rat Monoclonal détecte spécifiquement RAGE dans WB, IF et IHC (fro). Il présente une réactivité envers Souris et a été mentionné dans 1 publication.

Aperçu rapide pour RAGE anticorps (Extracellular Domain) (ABIN360934)

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp RAGE est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 2B65

Détail du produit anti-RAGE anticorps

Épitope: Extracellular Domain

Specificité: This antibody detects RAGE.

Purification: Protein A/G Affinity Chromatography

Immunogène: Mouse Recombinant RAGE extracellular domain. Remarks: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized rat).

Isotype: IgG2

Information d'application

Indications d'application: Western Blot: 1/500-1/1000. Immunohistochemistry on Frozen Sections: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Concentration: 0,5 mg/mL

Buffer: PBS without preservatives

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-RAGE (ABIN360934)

Aue, Englert, Harrer, Schwiering, Gaab, König, Adams, Schmidtko, Friebe, Groneberg: "NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis." dans: Respiratory research, Vol. 24, Issue 1, pp. 167, (2023) (PubMed).

Détails sur RAGE

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Autre désignation: RAGE / AGER

Sujet: The Receptor for Advanced Glycation Endproducts (RAGE) is a member of the Immunoglobin superfamily of cell surface markers. This protein is able to interact with many molecules including: advanced glycation endproducts (AGE), amphoterin, and ligands. Research has shown that the accumulation of RAGE ligands in the biological system (endothelium mononuclear phagocytes, neurons and smooth muscle cells) can lead to destructive tissue diseases such as diabetic retinopathy, amyloidoses, tumors and inflammation disorders. RAGE is expressed by endothelium mononuclear phagocytes, smooth muscle and neurons.Synonyms: Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

ID gène: 10090

UniProt: Q62151

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins