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Metabotropic Glutamate Receptor 1 anticorps (C-Term)

GRM1 Reactivité: Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361416
  • Antigène Voir toutes Metabotropic Glutamate Receptor 1 (GRM1) Anticorps
    Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))
    Épitope
    • 15
    • 15
    • 10
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 64
    • 46
    • 44
    • 15
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 76
    • 18
    • 2
    • 1
    Lapin
    Clonalité
    • 72
    • 25
    Polyclonal
    Conjugué
    • 44
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Metabotropic Glutamate Receptor 1 est non-conjugé
    Application
    • 50
    • 30
    • 25
    • 25
    • 18
    • 17
    • 14
    • 14
    • 13
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Specific for the ~125k monomer and the ~250k mGluR1a dimer. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.
     Réactivité croisée
    Souris, Rat (Rattus)
    Purification
    Antigen Affinity Purified
    Immunogène
    Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH
    Top Product
    Discover our top product GRM1 Anticorps primaire
  • Indications d'application
    Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:500 Quality Control: Western blots performed on each lot.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
    Stock
    -20 °C
  • Antigène
    Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))
    Autre désignation
    GRM1 (GRM1 Produits)
    Synonymes
    anticorps fj39d05, anticorps wu:fj39d05, anticorps si:ch211-51a19.1, anticorps Glura, anticorps mGlutR, anticorps GB18621, anticorps GPRC1A, anticorps MGLU1, anticorps MGLUR1, anticorps SCAR13, anticorps 4930455H15Rik, anticorps ENSMUSG00000075319, anticorps Gm10828, anticorps Gprc1a, anticorps mGluR1, anticorps nmf373, anticorps rcw, anticorps wobl, anticorps glutamate metabotropic receptor 1, anticorps glutamate receptor, metabotropic 1a, anticorps metabotropic glutamate receptor 1, anticorps glutamate receptor, metabotropic 1, anticorps GRM1, anticorps grm1a, anticorps mGlutR1, anticorps Grm1
    Sujet
    The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). Anti-mGluR1a Western blot of 10 ug of HEK 293 cells expressing mGluR1a and mGluR5 showing the specific immunolabeling of the ~125k monomer and the ~250k dimer of mGluR1a. The mGluR1a antibody shows no reactivity toward mGluR5.
    Poids moléculaire
    125/250 kDa
    ID gène
    24414
    UniProt
    P23385
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