GABRG2 anticorps (pSer327)

N° du produit ABIN361470

Détail du produit anti-GABRG2 anticorps

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Épitope: pSer327

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRG2 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for ~45k GABAA receptor gamma2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by lambda phosphatase treatment.

Réactivité croisée: Souris, Rat (Rattus)

Homologie: bovine, canine, chicken, human, non-human primate

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-GABRG2 (ABIN361470)

Bohnsack, Carlson, Morrow: "Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons." dans: Neuropharmacology, Vol. 105, pp. 124-32, (2016) (PubMed).

Détails sur GABRG2

Antigène: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Autre désignation: GABRG2 (GABRG2 Produits)

Synonymes: anticorps cae2, anticorps eca2, anticorps gabrg1, anticorps gefsp3, anticorps si:ch211-145n14.1, anticorps CAE2, anticorps ECA2, anticorps GEFSP3, anticorps GABAA-R, anticorps Gabrg-2, anticorps gamma2, anticorps gamma-aminobutyric acid type A receptor gamma2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, gamma 2, anticorps gamma-aminobutyric acid type A receptor gamma 2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2, anticorps GABRG2, anticorps gabrg2, anticorps Gabrg2

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. It has recently been suggested that PKC regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)

Poids moléculaire: '45 kDa

ID gène: 29709

UniProt: P18508