ELK1 anticorps (pSer383)

N° du produit ABIN361487

Détail du produit anti-ELK1 anticorps

Antigène: ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))

Épitope: pSer383

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ELK1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for ~46k Elk-1 phosphorylated at Ser383. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.

Réactivité croisée: Souris, Rat (Rattus)

Homologie: canine, human, mouse, non-human primate, zebra fish

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser383 conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur ELK1

Antigène: ELK1 (ELK1, Member of ETS Oncogene Family (ELK1))

Autre désignation: ELK1 (ELK1 Produits)

Synonymes: anticorps Elk-1, anticorps Xelk, anticorps Xelk-1, anticorps elk-1, anticorps elk1, anticorps ELK1, ETS transcription factor, anticorps ELK1, member of ETS oncogene family, anticorps ETS domain-containing protein Elk-1, anticorps ELK1, member of ETS oncogene family S homeolog, anticorps ELK1, anticorps Elk1, anticorps Tsp_02690, anticorps elk1, anticorps elk1.S

Sujet: Elk-1 is a transcription factor involved in mediating gene transcription in response to growth factors (Hill and Treisman, 1995). Elk-1 is thought to be phosphorylated by MAP kinase at Ser383 and phosphorylation at this site is essential for the transcriptional activity of Elk-1 (Li et al., 2003). Phosphorylation of Elk-1 has also been implicated in synaptic plasticity in the adult hippocampus (Thiels et al., 2002). Anti-Phospho Ser383 Elk-1 Western blot of recombinant Elk-1 showing specific immunolabeling of the ~46k Elk-1 phosphorylated at Ser383 (Phos). The immunolabeling is absent in dephospho-Elk-1 (Non-Phos).

Poids moléculaire: '46 kDa

ID gène: 2002

UniProt: P19419

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling