MAP2K5 anticorps (pSer311, pThr315)

N° du produit ABIN361510

Détail du produit anti-MAP2K5 anticorps

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Épitope: pSer311, pThr315

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP2K5 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~49k MEK5 protein phosphorylated at Ser311, Thr315. Immunolabeling of the MEK5 band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.

Réactivité croisée: Rat (Rattus)

Homologie: bovine, canine, chicken, human, mouse, non-human primates, Xenopus, zebra fish

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser311/Thr315 conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur MAP2K5

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Autre désignation: MAP2K5 (MAP2K5 Produits)

Synonymes: anticorps Mek5, anticorps HsT17454, anticorps MAPKK5, anticorps MEK5, anticorps PRKMK5, anticorps AI324775, anticorps AI428457, anticorps Mapkk5, anticorps Prkmk5, anticorps fb73f02, anticorps wu:fb73f02, anticorps zgc:172137, anticorps ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5, anticorps ATMAP2K_ALPHA, anticorps ATMEK5, anticorps ATMKK5, anticorps MAP KINASE KINASE 5, anticorps MAP kinase kinase 5, anticorps MAP2K_A, anticorps mitogen activated protein kinase kinase 5, anticorps mitogen-activated protein kinase kinase 5, anticorps mitogen-activated protein kinase kinase 5 L homeolog, anticorps MAP kinase kinase 5, anticorps Map2k5, anticorps MAP2K5, anticorps map2k5, anticorps map2k5.L, anticorps MKK5

Sujet: MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004). Anti-Phospho-Ser311, Thr315 MEK5 Western blot of rat testes lysate showing specific labeling of the ~49k MEK5 protein (Control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

Poids moléculaire: '49 kDa

ID gène: 31068

UniProt: Q62862

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway