Nibrin anticorps (pSer343)

N° du produit ABIN361984

Détail du produit anti-Nibrin anticorps

Antigène: Nibrin (NBN)

Épitope: pSer343

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody detects endogenous level of p95/NBS1 only when phosphorylated at serine 343.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène: Peptide sequence around phosphorylation site of pSer343 (S-L-S (p) -Q-G) derived from Human p95, NBS1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Références pour anticorps anti-Nibrin (ABIN361984)

Drissi, Wu, Hu, Bockhold, Dome: "Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells." dans: Cancer prevention research (Philadelphia, Pa.), Vol. 4, Issue 12, pp. 1973-81, (2011) (PubMed).

Carrillo, Schneider, Taylor, Srinivasan, Kapoor, Bhatia: "Prominent oromandibular dystonia and pharyngeal telangiectasia in atypical ataxia telangiectasia." dans: Cerebellum (London, England), Vol. 8, Issue 1, pp. 22-7, (2009) (PubMed).

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: p95/NBS1 (NBN Produits)

Synonymes: anticorps NBN, anticorps AT-V1, anticorps AT-V2, anticorps ATV, anticorps NBS, anticorps NBS1, anticorps P95, anticorps Nbs1, anticorps im:6911679, anticorps zgc:194152, anticorps nibrin, anticorps NBN, anticorps nbn, anticorps Nbn

Sujet: Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Poids moléculaire: 95 kDa

NCBI Accession: NP_002476

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response