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IGF1R anticorps (pTyr1166)
IGF1R
Reactivité: Humain, Souris, Rat
WB, IF
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-IGF1R anticorps
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Antigène
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IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Épitope
Tous les épitopes à travers IGF1R Anticorps.
pTyr1166
Reactivité
Toutes les réactivités sur IGF1R Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur IGF1R Anticorps
Lapin
Clonalité
Toutes les clonalités sur IGF1R Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers IGF1R Anticorps
Cet anticorp IGF1R est non-conjugé
Application
Tous les applications à travers IGF1R Anticorps.
Western Blotting (WB), Immunofluorescence (IF)
Specificité
The antibody detects endogenous level of IGF-1R only when phosphorylated at tyrosine 1165/tyrosine1166.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
Immunogène
Peptide sequence around phosphorylation site of pTyr 1165, pTyr1166 (T-D-Y (p) -Y (p) -R-K) derived from Human IGF-1R . Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype
IgG
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Information d'application
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Indications d'application
Western blotting: 1:500-1:1000 Immunofluorescence: 1:100-1:200
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C/-20 °C
Stockage commentaire
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Références pour anticorps anti-IGF1R (ABIN362040)
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Han, Quirion, Zheng : "WITHDRAWN: Glutamate Attenuates IGF-1 Receptor Signaling via NR2B containing NMDA Receptors 3 and neuronal Nitric Oxide Synthase. " dans: Biochemical and biophysical research communications , (2011 ) (PubMed ).
Détails sur IGF1R
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Antigène
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Autre désignation
IGF-1R (IGF1R Produits )
Synonymes
anticorps CMT2N, anticorps CD221, anticorps IGFIR, anticorps IGFR, anticorps JTK13, anticorps IGFIRC, anticorps IGFR1, anticorps IGF-1R, anticorps IGF1R, anticorps DKFZp469I0618, anticorps igf-1r, anticorps xIGF-1R, anticorps xIGFR, anticorps xigf1r, anticorps A330103N21Rik, anticorps D930020L01, anticorps hyft, anticorps igf-ir, anticorps IGF-IR, anticorps IGF-IRb, anticorps wu:fb03h06, anticorps IGF-IRa, anticorps sb:eu1090, anticorps wu:fi20b10, anticorps alanyl-tRNA synthetase, anticorps insulin like growth factor 1 receptor, anticorps insulin-like growth factor 1 receptor, anticorps insulin-like growth factor 1, anticorps insulin-like growth factor I receptor, anticorps insulin like growth factor 1 receptor S homeolog, anticorps insulin-like growth factor 1b receptor, anticorps insulin-like growth factor 1a receptor, anticorps AARS, anticorps IGF1R, anticorps Igf1r, anticorps igf1r, anticorps Igf1, anticorps LOC780503, anticorps LOC100136427, anticorps igf1r.S, anticorps igf1rb, anticorps igf1ra
Sujet
This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.
Poids moléculaire
95 kDa
NCBI Accession
NP_000866
UniProt
P08069
Pathways
Signalisation RTK , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Autophagy
Vus récemment
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