TYK2 anticorps (pTyr1054)
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- Antigène Voir toutes TYK2 Anticorps
- TYK2 (Tyrosine Kinase 2 (TYK2))
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Épitope
- pTyr1054
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TYK2 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- The antibody detects endogenous level of TYK2 only when phosphorylated at tyrosine 1054.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Immunogène
- Peptide sequence around phosphorylation site of pTyr1054 (H-E-Y (p) -Y-R) derived from Human TYK2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Isotype
- IgG
- Top Product
- Discover our top product TYK2 Anticorps primaire
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- Indications d'application
- Western blotting: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Antigène
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Autre désignation
- TYK2 (TYK2 Produits)
- Synonymes
- anticorps JTK1, anticorps tyrosine kinase 2, anticorps TYK2, anticorps Tyk2
- Sujet
- TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin
- Poids moléculaire
- 140 kDa
- NCBI Accession
- NP_003322
- UniProt
- P29597
- Pathways
- Signalistation JAK/STAT, Hepatitis C
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