CDK1 anticorps (pTyr15)

N° du produit ABIN362297

Il existe 2+ publications pour ce produit. L’anticorps anti-CDK1 Polyclonal Lapin est utilisé pour la détection de CDK1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CDK1 anticorps (pTyr15) (ABIN362297)

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK1 est non-conjugé

Application: Veuillez nous consulter SVP

Détail du produit anti-CDK1 anticorps

Épitope: pTyr15

Specificité: The antibody detects endogenous level of CDC2 only when phosphorylated at tyrosine 15.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène: Peptide sequence around phosphorylation site of pTyr15 (G-T-Y (p) -G-V) derived from Human CDC2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Références pour anticorps anti-CDK1 (ABIN362297)

Kubara, Kernéis-Golsteyn, Studény, Lanser, Meijer, Golsteyn: "Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents." dans: The Biochemical journal, Vol. 446, Issue 3, pp. 373-81, (2012) (PubMed).

Yao, Li, Liu, Huang, Guo: "SUMOylation-regulated protein phosphorylation, evidence from quantitative phosphoproteomics analyses." dans: The Journal of biological chemistry, Vol. 286, Issue 31, pp. 27342-9, (2011) (PubMed).

Détails sur CDK1

Antigène: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Autre désignation: CDC2

Sujet: Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.

Poids moléculaire: 34 kDa

NCBI Accession: NP_001163

UniProt: P06493

Pathways: Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA