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Nibrin anticorps (AA 341-345)

NBN Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated

N° du produit ABIN362592

Fiche de données

Antigène Voir toutes Nibrin (NBN) Anticorps

Nibrin (NBN)
Épitope
36

15

12

8

7

5

5

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 341-345
Reactivité
98

60

36

2

1

1

1

1
Humain
Hôte
115

15
Lapin
Anticorps secondaires appropriés
Clonalité
106

24
Polyclonal
Conjugué
64

8

6

6

6

6

6

6

5

3

2

2

2

2

2

2

2
Cet anticorp Nibrin est non-conjugé
Application
101

45

27

27

26

25

23

17

9

8

6

4

2

2

1
Western Blotting (WB), Immunohistochemistry (IHC)

Specificité

The antibody detects endogenous level of total p95/NBS1 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène

Peptide sequence around AA 341-345 (S-L-S-Q-G) derived from Human p95, NBS1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype

IgG

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Indications d'application

Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C/-20 °C

Stockage commentaire

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Antigène

Nibrin (NBN)

Autre désignation

p95/NBS1 (NBN Produits)

Synonymes

anticorps NBN, anticorps AT-V1, anticorps AT-V2, anticorps ATV, anticorps NBS, anticorps NBS1, anticorps P95, anticorps Nbs1, anticorps im:6911679, anticorps zgc:194152, anticorps nibrin, anticorps NBN, anticorps nbn, anticorps Nbn

Sujet

Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Poids moléculaire

95 kDa

NCBI Accession

NP_002476

UniProt

O60934

Pathways

Réparation de l'ADN, Production of Molecular Mediator of Immune Response