Nibrin anticorps (AA 341-345)

N° du produit ABIN362591

L’anticorps anti-Nibrin Polyclonal Lapin est utilisé pour la détection de Nibrin dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour Nibrin anticorps (AA 341-345) (ABIN362591)

Antigène: Nibrin (NBN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Nibrin anticorps

Épitope: AA 341-345

Specificité: The antibody detects endogenous level of total p95/NBS1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Peptide sequence around AA 341-345 (S-L-S-Q-G) derived from Human p95, NBS1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: p95/NBS1

Sujet: Mutations in p95/NBS1 gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

Poids moléculaire: 95 kDa

NCBI Accession: NP_002476

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response