FLT3 anticorps (AA 589-593)

N° du produit ABIN362818

Cité dans 2 publications. Cet anticorps anti-FLT3 Polyclonal Lapin (ABIN362818) détecte spécifiquement FLT3 dans IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour FLT3 anticorps (AA 589-593) (ABIN362818)

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FLT3 est non-conjugé

Application: Immunofluorescence (IF)

Détail du produit anti-FLT3 anticorps

Épitope: AA 589-593

Specificité: The antibody detects endogenous level of total FLT3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

Immunogène: Peptide sequence around AA 589-593 (Y-F-Y-V-D) derived from Human FLT3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Références pour anticorps anti-FLT3 (ABIN362818)

Ninagawa, Murakami, Isobe, Tanaka, Nakagawa, Torihashi: "Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits." dans: Differentiation; research in biological diversity, Vol. 82, Issue 3, pp. 153-64, (2011) (PubMed).

Meads, Nouwen: "Does emotional disclosure have any effects? A systematic review of the literature with meta-analyses." dans: International journal of technology assessment in health care, Vol. 21, Issue 2, pp. 153-64, (2005) (PubMed).

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: FLT3

Sujet: FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Poids moléculaire: 160 kDa

NCBI Accession: NP_004110

UniProt: P36888

Pathways: Signalisation RTK