NFKBIB anticorps (pSer23)

N° du produit ABIN363148

Détail du produit anti-NFKBIB anticorps

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Épitope: pSer23

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFKBIB est non-conjugé

Application: Immunohistochemistry (IHC)

Specificité: The antibody detects endogenous level of IkB-b only when phosphorylated at serine 23.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène: Peptide sequence around phosphorylation site of pSer23 (L-G-S (p) -L-G) derived from Human IkB-b. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry: 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur NFKBIB

Antigène: NFKBIB (NF-kappa-B inhibitor beta (NFKBIB))

Autre désignation: IkappaB-beta (NFKBIB Produits)

Synonymes: anticorps NFKBIB, anticorps IKB-beta, anticorps IKappaBbeta, anticorps IkB, anticorps IkBb, anticorps IKBB, anticorps TRIP9, anticorps NFKB inhibitor beta, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta, anticorps NFKBIB, anticorps Nfkbib

Sujet: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Poids moléculaire: 48 kDa

NCBI Accession: NP_001001

UniProt: Q15653

Pathways: Signalisation NF-kappaB, Activation of Innate immune Response, Maintenance of Protein Location, Toll-Like Receptors Cascades