p300 anticorps (AA 1572-2371)

N° du produit ABIN363282

Cet anticorps anti-p300 Monoclonal Souris (Clone RW128) (ABIN363282) détecte spécifiquement p300 dans WB, IP, IF et ICC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Singe et Vison.

Aperçu rapide pour p300 anticorps (AA 1572-2371) (ABIN363282)

Antigène: p300 (EP300) (E1A Binding Protein P300 (EP300))

Reactivité: Humain, Souris, Rat, Singe, Vison

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp p300 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: RW128

Détail du produit anti-p300 anticorps

Épitope: AA 1572-2371

Specificité: Reacts with human p300 protein (residues 1868-1921)

Réactivité croisée: Souris

Réactivité croisée (Details): Cross reacts with proteins from mouse, rat, monkey and mink.

Purification: Purified (protein A)

Immunogène: Fusion protein containing residues 1572-2371 of human p300

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:10-1:2000, IP1:10-1:500, WB1:250-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, Sodium azide 0.1 %

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C/-80 °C

Stockage commentaire: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Détails sur p300

Antigène: p300 (EP300) (E1A Binding Protein P300 (EP300))

Autre désignation: p300

Sujet: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.

ID gène: 2033

UniProt: Q09472

Pathways: Signalisation p53, Signalisation Notch, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size