KIT anticorps (Biotin)

N° du produit ABIN371417

L’anticorps Souris Monoclonal anti-KIT a été validé pour FACS. Il convient pour détecter KIT dans des échantillons de Poulet.

Aperçu rapide pour KIT anticorps (Biotin) (ABIN371417)

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivité: Poulet

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KIT est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Clone: Kit2c75

Détail du produit anti-KIT anticorps (Biotin)

Specificité: This antibody recognizes Chicken c-Kit.

Attributs du produit: Synonyms: SCFR, KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase

Immunogène: Sp2/0 cells, Sp/chkit4A4, transfected with Chicken c-kit cDNA. Remarks: The amino acid sequence of Chicken c-kit shows 63% identity to Mouse c-Kit andexhibits similar expression patterns in RNA blot analysis suggesting similar biologicalroles. (Ref. 1)

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry: < / = 1 μg/10^6 cells. (Ref.6-10)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur KIT

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Autre désignation: CD117 / C-Kit

Sujet: C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR

ID gène: 378783

UniProt: Q08156

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity