CGRP anticorps

N° du produit ABIN371823

Détail du produit anti-CGRP anticorps

Antigène: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Reactivité: Humain, Rat, Mammifères

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CGRP est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody is specific for Calcitonin Gene Related Peptide. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP). Suggested Positive Controls: Dorsal root ganglia, pancreas and gut.

Réactivité croisée (Details): Species reactivity (expected):most Mammals.
Species reactivity (tested):Human and Rat.

Attributs du produit: Synonyms: Calcitonin gene-related peptide I, Alpha-type CGRP, CALC1, CGRP-I

Purification: Protein G Chromatography.

Clone: 4901

Isotype: IgG2a

Information d'application

Indications d'application: Immunocytochemistry: 1/50-1/100. Immunofluorescence and Immunohistochemistry: This antibody is an excellent tool forImmunohistochemistry and for multiple labeling immunofluorescence of peripheral tissuelike stomach, intestine, pancreas, sensory ganglia, and all the regions of the body that areinnervated by primary afferent neurons as well as central nervous tissue. Suggested Positive Controls: Dorsal root ganglia, pancreas and gut. Not recommended for Western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CGRP

Antigène: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Autre désignation: CGRP / CALCA (CALCA Produits)

Synonymes: anticorps CALC1, anticorps CGRP, anticorps CGRP-I, anticorps CGRP1, anticorps CT, anticorps KC, anticorps CALC, anticorps CALCA, anticorps CALC3, anticorps ci-ct, anticorps calca, anticorps CA, anticorps CGRP-1, anticorps Calc, anticorps Calc1, anticorps Cgrp, anticorps Ct, anticorps Ctn, anticorps calcitonin, anticorps CAL6, anticorps Cal1, anticorps RATCAL6, anticorps CGRPI, anticorps calc, anticorps cgrp, anticorps zgc:92886, anticorps calcitonin related polypeptide alpha, anticorps calcitonin related polypeptide beta, anticorps calcitonin-related polypeptide alpha, anticorps calcitonin, anticorps calcitonin/calcitonin-related polypeptide, alpha, anticorps calcitonin-related polypeptide beta, anticorps calcitonin gene-related peptide 2, anticorps CALCA, anticorps CALCB, anticorps ci-ct, anticorps calca, anticorps Calca, anticorps LOC100008771

Sujet: Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in Immunoneutralization (Wong et al., 1993)Synonyms: Alpha-type CGRP, CALC1, CGRP-I, Calcitonin gene-related peptide I

ID gène: 796

UniProt: P06881

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour