SMAD2 anticorps (AA 234-249)

N° du produit ABIN372441

Cet anticorps anti-SMAD2 est un anticorps Lapin Polyclonal détectant SMAD2 dans WB et IHC (p). Adapté pour Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien et Chimpanzé.

Aperçu rapide pour SMAD2 anticorps (AA 234-249) (ABIN372441)

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien, Chimpanzé

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-SMAD2 anticorps

Épitope: AA 234-249

Séquence: DQQLNQSMDT GSPAEL

Specificité: This antibody recognizes SMAD, Mothers Against DPP Homolog 2 (SMAD2).

Réactivité croisée (Details): Species reactivity (expected):Bovine (Cow), Chimpanzee, Chicken, Dog (Canine), Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogène: Synthetic peptide corresponding to Amino acids 234-249 of human SMAD2.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 2-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA as stabilizer and 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur SMAD2

Antigène: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Autre désignation: SMAD2

Sujet: SMAD2 is an intracellular protein belonging to the Dwarfin (DWA/B)/SMAD family. SMAD2 associates with SMAD4 for translocation to nucleus. It acts as an intracellular mediator of TGFbeta family of cytokines and activin type 1 receptor (ACVR1C). Hence it regulates multiple cellular processes like cell growth, proliferation, differentiation, and apoptosis and also cooperates with transcription factors to regulate expression of defined genes. Apart from playing an important role in TGFbeta1-induced CTGF expression they also act as markers of EMT in human PTECs. It also acts as an integrator of multiple signals in the regulation of NOS3 expression. It is ubiquitously expressed in most of the tissues and is responsible for colorectal, hepatocellular, lung and breast carcinomas as well as cervical cancer.Synonyms: JV18-1, MAD homolog 2, MADH2, MADR2, Mad-related protein 2, Mothers against DPP homolog 2, Mothers against decapentaplegic homolog 2, SMAD 2, SMAD family member 2, SMAD-2

ID gène: 4087

NCBI Accession: NP_001003652

UniProt: Q15796

Pathways: Cycle Cellulaire, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus