SNCA anticorps (pSer129)
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- Antigène Voir toutes SNCA Anticorps
- SNCA (Synuclein, alpha (SNCA))
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Épitope
- pSer129
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Reactivité
- Humain, Rat, Souris, Boeuf (Vache), Chien, Non-Human Primate
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SNCA est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- Recognizes the ~15 kDa alpha-Synuclein protein phosphorylated at Ser129. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
- Réactivité croisée (Details)
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Species reactivity (expected):Bovine, Canine, Human, Mouse and non-Human Primates.
Species reactivity (tested):Rat. - Purification
- Affinity Chromatography.
- Immunogène
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser129 of alpha Synuclein.
- Isotype
- IgG
- Top Product
- Discover our top product SNCA Anticorps primaire
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- Indications d'application
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Antigène
- SNCA (Synuclein, alpha (SNCA))
- Autre désignation
- alpha-Synuclein / SNCA (SNCA Produits)
- Synonymes
- anticorps snca, anticorps MGC64356, anticorps LOC619283, anticorps NACP, anticorps alphaSYN, anticorps PARK1, anticorps PARK4, anticorps PD1, anticorps synuclein alpha L homeolog, anticorps alpha-synuclein, anticorps synuclein alpha, anticorps synuclein, alpha, anticorps snca.L, anticorps LOC619283, anticorps SNCA, anticorps Snca
- Sujet
- Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Mutation of the alpha-synuclein gene is associated with familial forms of PD (Newmann et al., 2002). Recent evidence suggests that phosphorylation of alpha-synuclein at ser129 plays a role in the formation of inclusions in PD (Smith et al., 2005, Masliah et al., 2005).Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
- ID gène
- 29219
- NCBI Accession
- NP_062042
- UniProt
- P37377
- Pathways
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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