Connexin 43/GJA1 anticorps (C-Term)

N° du produit ABIN372602

L’anticorps Lapin Polyclonal anti-Connexin 43/GJA1 a été validé pour WB. Il convient pour détecter Connexin 43/GJA1 dans des échantillons de Humain, Rat, Souris, Chien, Poulet, Poisson zèbre (Danio rerio), Mouton, Xenopus laevis, Non-Human Primate et Pinson.

Aperçu rapide pour Connexin 43/GJA1 anticorps (C-Term) (ABIN372602)

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reactivité: Humain, Rat, Souris, Chien, Poulet, Poisson zèbre (Danio rerio), Mouton, Xenopus laevis, Non-Human Primate, Pinson

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Connexin 43/GJA1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Connexin 43/GJA1 anticorps

Épitope: C-Term

Specificité: Specific for the ~43k Connexin-43 protein.

Réactivité croisée (Details): Species reactivity (expected):Human, Chicken, Canine (Dog), Finch, Mouse, Sheep, Xenopus, Zebrafish and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogène: Peptide corresponding to amino acid residues from the C-terminal region of rat Connexin-43.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur Connexin 43/GJA1

Antigène: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Autre désignation: GJA1 / Cx43

Sujet: Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).Synonyms: Connexin-43, GJAL, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein

ID gène: 2697

NCBI Accession: NP_000156

UniProt: P17302

Pathways: Signalisation MAPK, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization