MAP2K5 anticorps (pSer311, pThr315)

N° du produit ABIN372667

Cet anticorps Lapin Polyclonal détecte spécifiquement MAP2K5 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Chien, Boeuf (Vache), Poulet, Xenopus laevis, Poisson zèbre (Danio rerio) et Non-Human Primate.

Aperçu rapide pour MAP2K5 anticorps (pSer311, pThr315) (ABIN372667)

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Poulet, Xenopus laevis, Poisson zèbre (Danio rerio), Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP2K5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MAP2K5 anticorps

Épitope: pSer311, pThr315

Specificité: This antibody is specific for the ~49k MEK5 protein phosphorylated at Ser311, Thr315. Immunolabeling of the MEK5 band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Human, Chicken, Bovine, Canine, non-Human Primates, Xenopus, and Zebrafish.
Species reactivity (tested):Rat.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser311, Thr315 of MEK5.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur MAP2K5

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Autre désignation: MAP2K5

Sujet: MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004).Synonyms: Dual specificity mitogen-activated protein kinase kinase 5, MAP kinase kinase 5, MAPKK 5, MEK5, MKK5

ID gène: 29568

NCBI Accession: NP_001029159

UniProt: Q62862

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway