Metabotropic Glutamate Receptor 1 anticorps (C-Term)

N° du produit ABIN372668

L’anticorps anti-Metabotropic Glutamate Receptor 1 Polyclonal Lapin est utilisé pour la détection de Metabotropic Glutamate Receptor 1 dans des échantillons de Rat. Il a été validé pour WB et IHC (fro).

Aperçu rapide pour Metabotropic Glutamate Receptor 1 anticorps (C-Term) (ABIN372668)

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Metabotropic Glutamate Receptor 1 anticorps

Épitope: C-Term

Specificité: This antibody is specific for the ~125k monomer and the ~250k mGluR1a dimer. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.

Réactivité croisée (Details): Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogène: Peptide from the C-terminal region of Rat mGluR1a.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur Metabotropic Glutamate Receptor 1

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Autre désignation: mGluR1a / GRM1a

Sujet: The metabotropic Glutamate Receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003).Synonyms: Gprc1a, Metabotropic glutamate receptor 1, Mglur1

ID gène: 24414

NCBI Accession: NP_001107802

UniProt: P23385