Metabotropic Glutamate Receptor 1 anticorps (C-Term)

N° du produit ABIN372668

Détail du produit anti-Metabotropic Glutamate Receptor 1 anticorps

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Épitope: C-Term

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody is specific for the ~125k monomer and the ~250k mGluR1a dimer. Immunolabeling blocked by preadsorption of antibody with the peptide used to generate the antibody.

Réactivité croisée (Details): Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogène: Peptide from the C-terminal region of Rat mGluR1a.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur Metabotropic Glutamate Receptor 1

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Autre désignation: mGluR1a / GRM1a (GRM1 Produits)

Synonymes: anticorps fj39d05, anticorps wu:fj39d05, anticorps si:ch211-51a19.1, anticorps Glura, anticorps mGlutR, anticorps GB18621, anticorps GPRC1A, anticorps MGLU1, anticorps MGLUR1, anticorps SCAR13, anticorps 4930455H15Rik, anticorps ENSMUSG00000075319, anticorps Gm10828, anticorps Gprc1a, anticorps mGluR1, anticorps nmf373, anticorps rcw, anticorps wobl, anticorps glutamate metabotropic receptor 1, anticorps glutamate receptor, metabotropic 1a, anticorps metabotropic glutamate receptor 1, anticorps glutamate receptor, metabotropic 1, anticorps GRM1, anticorps grm1a, anticorps mGlutR1, anticorps Grm1

Sujet: The metabotropic Glutamate Receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003).Synonyms: Gprc1a, Metabotropic glutamate receptor 1, Mglur1

ID gène: 24414

NCBI Accession: NP_001107802

UniProt: P23385