UCHL1 anticorps

N° du produit ABIN372739

Cet anticorps Poulet Polyclonal détecte spécifiquement UCHL1 dans WB, IF et IHC (fro). Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Boeuf (Vache) et Mammifères.

Aperçu rapide pour UCHL1 anticorps (ABIN372739)

Antigène: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Mammifères

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp UCHL1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-UCHL1 anticorps

Specificité: Specific for the the ~24 kDa UCHL1 protein.

Réactivité croisée (Details): Species reactivity (expected):Mamalia.
Species reactivity (tested):Bovine, Human, Mouse and Rat.

Purification: Ig Fraction

Immunogène: Recombinant full length human UCHL1 purified from E. coli.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western blotting: 1/2,500. Immunofluorescence: 1/500. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur UCHL1

Antigène: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Autre désignation: UCHL1 / PGP9.5

Sujet: Ubiquitin C-terminal hydrolase 1 (UCHL1) is also known as ubiquitin carboxyl esterase L1, ubiquitin thiolesterase, neuron-specific protein PGP9.5 and Park5. It was originally identified as a major component of the neuronal cytoplasm from 2-dimensional gel analysis of brain tissues, and was given the name PGP9.5 (1). It was later found that ubiquitin C-terminal hydrolase enzyme activity was associated with the PGP9.5 protein (2). The ubiquitin C-terminal hydrolases cleave ubiquitin from other molecules. Regulation of the ubiquitin pathway is very important and many disease states are associated with defects in this pathway. Genetic knockout of UCHL1 in mice results in a motor neuron degeneration similar to the spontaneous gracile axonal dystrophy (gad) mutant mice (3). Point mutations in the UCHL1 gene are associated with some forms of human Parkinson's disease (4). Since UCHL1 is heavily expressed in neurons, it is released in large amounts following injury or degeneration, so the detection of UCHL1 in CSF and other bodily fluids can be used as a biomarker.Synonyms: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1

ID gène: 7345

NCBI Accession: NP_004172

UniProt: P09936

Pathways: Feeding Behaviour