NOD2 anticorps (C-Term)

N° du produit ABIN372922

Cet anticorps Lapin Polyclonal détecte spécifiquement NOD2 dans WB, IF, IHC (p) et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour NOD2 anticorps (C-Term) (ABIN372922)

Antigène: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOD2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-NOD2 anticorps

Épitope: C-Term

Specificité: This antibody recognizes NOD2 Protein (CARD15).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: Synthetic peptide - KLH conjugated corresponding to 14 amino acids at the carboxy terminus of Human NOD2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2-4 μg/mL. Immunocytochemistry: 10 μg/mL. Immunohistochemistry on Paraffin Sections: 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur NOD2

Antigène: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Autre désignation: CARD15 / NOD2

Sujet: CARD15 (Nod2) is a member of the Nod1/Apaf-1 family of intracellular proteins that contain an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and a C-terminal regulatory domain. CARD15 induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It also confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Unlike Nod1, this homologue is primary expressed in monocytes. Defects in CARD15 are associated with Blau Syndrome (BS) and Crohn's Disease (CD), and are a cause of susceptibility to ulcerative colitis.Synonyms: Caspase recruitment domain-containing protein 15, IBD1, Inflammatory bowel disease protein 1, Nucleotide-binding oligomerization domain-containing protein 2

ID gène: 64127

NCBI Accession: NP_071445

UniProt: Q9HC29

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome