Patched 1 anticorps (Internal Region)

N° du produit ABIN374710

Cet anticorps Chèvre Polyclonal détecte spécifiquement Patched 1 dans WB, IF et EIA. Il présente une réactivité envers Humain, Souris, Chien, Boeuf (Vache) et Porc.

Aperçu rapide pour Patched 1 anticorps (Internal Region) (ABIN374710)

Antigène: Patched 1 (PTCH1)

Reactivité: Humain, Souris, Chien, Boeuf (Vache), Porc

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Patched 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-Patched 1 anticorps

Épitope: Internal Region

Specificité: This antibody detects PTCH.

Réactivité croisée (Details): Species reactivity (expected):Canine (Dog), Pig, Cow.
Species reactivity (tested):Human, Mouse.

Purification: Affinity Chromatography

Immunogène: Peptide with sequence C-HPESRHHPPSNPRQQ from the internal region of the protein sequence Genename: PTCH

Information d'application

Indications d'application: ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide and 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Patched 1

Antigène: Patched 1 (PTCH1)

Autre désignation: PTCH1

Sujet: PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehogs proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome.Synonyms: PTC, PTC1, PTCH, Patched 1, Protein patched homolog 1

ID gène: 5727

NCBI Accession: NP_000255

UniProt: Q13635

Pathways: Signalisation Hedgehog, Carbohydrate Homeostasis, Tube Formation