Patched 1 anticorps (AA 770-970)

N° du produit ABIN7269184

Détail du produit anti-Patched 1 anticorps

Antigène: Patched 1 (PTCH1)

Épitope: AA 770-970

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Patched 1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Fonction: PTCH1 Rabbit pAb

Séquence: RVRDGLDLTD IVPRETREYD FIAAQFKYFS FYNMYIVTQK ADYPNIQHLL YDLHRSFSNV KYVMLEENKQ LPKMWLHYFR DWLQGLQDAF DSDWETGKIM PNNYKNGSDD GVLAYKLLVQ TGSRDKPIDI SQLTKQRLVD ADGIINPSAF YIYLTAWVSN DPVAYAASQA NIRPHRPEWV HDKADYMPET RLRIPAAEPI E

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 770-970 of human PTCH1 (NP_000255.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Patched 1

Antigène: Patched 1 (PTCH1)

Autre désignation: PTCH1 (PTCH1 Produits)

Synonymes: anticorps BCNS, anticorps HPE7, anticorps NBCCS, anticorps PTC, anticorps PTC1, anticorps PTCH, anticorps PTCH11, anticorps lep, anticorps ptc1, anticorps ptc2, anticorps Ptch, anticorps Ptch2, anticorps Ptc-1, anticorps XPtc1, anticorps patched, anticorps patched1, anticorps A230106A15Rik, anticorps Ptc, anticorps Ptc1, anticorps mes, anticorps patched 1, anticorps patched 1 L homeolog, anticorps Protein patched homolog 1, anticorps PTCH1, anticorps ptch1, anticorps Ptch1, anticorps ptch1.L, anticorps ptc-1

Sujet: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.,PTCH1,BCNS,HPE7,NBCCS,PTC,PTC1,PTCH,PTCH11,patched 1,Cancer,Tumor suppressors,Signal Transduction,G protein signaling,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Hedgehog Signaling Pathway,Neuroscience,Stem Cells,PTCH1

Poids moléculaire: 144kDa/153kDa/160kDa/161kDa

ID gène: 5727

UniProt: Q13635

Pathways: Signalisation Hedgehog, Carbohydrate Homeostasis, Tube Formation